Apc Polyclonal Antibody for Rat(Rattus norvegicus) | EIAab.comApc Polyclonal Antibody for Rat(Rattus norvegicus)

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Apc (Gene name),

Adenomatous polyposis coli protein (Protein name ), APC_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Apc;

Protein name:

Adenomatous polyposis coli protein(Protein APC);

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Forms homooligomers and heterooligomers with APC2. Interacts with DIAPH1 and DIAPH2. Interacts with PDZ domains of DLG1 and DLG3. Associates with catenins. Binds axin. Interacts with ARHGEF4 (via N-terminus). Interacts with MAPRE1 (via C-terminus); probably required for APC targeting to the growing microtubule plus ends. Interacts with MAPRE2 and MAPRE3 (via C-terminus). Found in a complex consisting of ARHGEF4, APC and CTNNB1. Interacts with SCRIB; may mediate APC targeting to adherens junctions of epithelial cells. Interacts with SPATA13 (via N-terminus and SH3 domain). Interacts with ASAP1 (via SH3 domain) (By similarity). Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B.

Function:

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

Subcellular Location:

Cell junction adherens junction Cytoplasm cytoskeleton Cell projection lamellipodium Cell projection ruffle membrane Cytoplasm Cell membrane Associated with the microtubule network at the growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment (By similarity). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.

Protein Attributes:

Sequence length:

2842

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PSQIPTPVGS | STKKRDSKTD | STESSGAQSP | KRHSGSYLVT | SV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10116.ENSRNOP00000027691

SMR:

P70478

KEGG:

rno:24205

Pfam:

PF05972

UniGene:

Rn.88057

String:

P70478

UniGene:

Rn.156346

Uniprot:

P70478

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ELISA Kit for Rat Protein APC

Cat.:

E10944m

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Packing:

96T

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ELISA Kit for Rat Protein APC

Cat.:

E10944h

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Packing:

96T

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ELISA Kit for Rat Protein APC

Cat.:

E10944r

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MSDS:

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Packing:

96T

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CLIA Kit for Rat Protein APC

Cat.:

U10944h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat Protein APC

Cat.:

U10944m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat Protein APC

Cat.:

U10944r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat Protein APC

Cat.:

P10944Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat Protein APC

Protein for Rat Protein APC

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"cDNA cloning of the rat APC gene and assignment to chromosome 18."
Toyota M. , Ushijima T. , Kakiuchi H. , Watanabe M. , Imai K. , Yachi A. , Sugimura T. , Nagao M.
Mamm. Genome6:746-748(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Fischer 344/N.
tissue: Brain.
2.

"Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine."
Kakiuchi H. , Watanabe M. , Ushijima T. , Toyota M. , Imai K. , Weisburger J.H. , Sugimura T. , Nagao M.
Proc. Natl. Acad. Sci. U.S.A.92:910-914(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
strain: Fischer 344/N.
strain: Sprague-Dawley.
3.

"The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway."
Chen H.J. , Lin C.M. , Lin C.S. , Perez-Olle R. , Leung C.L. , Liem R.K.
Genes Dev.20:1933-1945(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH MACF1; CTNNB1; AXIN1 AND GSK3B
4.

"Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
Hoffert J.D. , Pisitkun T. , Wang G. , Shen R.-F. , Knepper M.A.
Proc. Natl. Acad. Sci. U.S.A.103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1714;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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